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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EEF2K
All Species:
27.27
Human Site:
S586
Identified Species:
60
UniProt:
O00418
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00418
NP_037434.1
725
82144
S586
H
H
I
L
A
D
V
S
L
K
E
T
E
E
N
Chimpanzee
Pan troglodytes
XP_001161085
725
82249
S586
H
H
I
L
A
D
V
S
L
K
E
T
E
E
N
Rhesus Macaque
Macaca mulatta
XP_001092565
725
82310
S586
H
H
I
L
A
D
V
S
L
K
E
T
E
E
N
Dog
Lupus familis
XP_536939
725
81954
S586
H
H
I
L
A
D
V
S
L
K
E
T
E
E
N
Cat
Felis silvestris
Mouse
Mus musculus
O08796
724
81720
S585
H
H
I
L
A
D
V
S
L
K
E
T
E
E
N
Rat
Rattus norvegicus
P70531
724
81471
S585
H
H
I
L
A
D
V
S
L
E
E
T
E
E
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508333
641
73286
K510
L
E
E
T
D
E
N
K
M
K
G
F
D
Y
L
Chicken
Gallus gallus
XP_414920
725
82845
T586
H
H
I
L
S
E
V
T
L
E
D
T
K
E
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001002740
706
80225
E567
H
H
I
L
P
E
I
E
L
E
P
S
E
E
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O01991
768
87807
K627
E
N
G
I
R
A
D
K
G
Q
K
P
C
D
L
Sea Urchin
Strong. purpuratus
XP_788087
683
78401
V543
D
V
L
T
E
V
S
V
P
S
D
D
E
D
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97.5
93
N.A.
89.9
90
N.A.
75.3
78.7
N.A.
64.6
N.A.
N.A.
N.A.
38.6
45.5
Protein Similarity:
100
99.5
98.7
96.6
N.A.
94.7
94.3
N.A.
81.9
89.5
N.A.
75.4
N.A.
N.A.
N.A.
56.3
60.6
P-Site Identity:
100
100
100
100
N.A.
100
93.3
N.A.
6.6
60
N.A.
53.3
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
100
N.A.
80
N.A.
N.A.
N.A.
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
55
10
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
10
0
0
0
10
55
10
0
0
0
19
10
10
19
0
% D
% Glu:
10
10
10
0
10
28
0
10
0
28
55
0
73
73
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
0
0
10
0
0
0
0
0
10
0
10
0
0
0
0
% G
% His:
73
73
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
73
10
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
19
0
55
10
0
10
0
0
% K
% Leu:
10
0
10
73
0
0
0
0
73
0
0
0
0
0
19
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
73
% N
% Pro:
0
0
0
0
10
0
0
0
10
0
10
10
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
10
0
10
55
0
10
0
10
0
0
0
% S
% Thr:
0
0
0
19
0
0
0
10
0
0
0
64
0
0
0
% T
% Val:
0
10
0
0
0
10
64
10
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _